[1,2,4] TRIAZOLO [4,3-A] PYRIDINE-3(2H)-ONE

Product Description

124Triazolo43apyridine32Hone is a heterocyclic compound with a fused triazolopyridine structure often of interest in medicinal and materials chemistry Below is a detailed description

 Chemical Information

 Chemical Name 124Triazolo43apyridine32Hone  

 Chemical Formula C6H5N3O  

 Molecular Weight 13512 gmol  

 Structure  

   A fused bicyclic system consisting of a pyridine ring and a 124triazole ring  

   A ketone group O is located at the 3rd position of the triazole ring  

   The compound exists in a tautomeric equilibrium between keto and enol forms depending on environmental conditions

 Physical Properties

 Appearance White to pale yellow crystalline solid  

 Melting Point Around 200250C depending on substituents and purity  

 Solubility  

   Soluble in polar solvents like dimethyl sulfoxide DMSO and methanol  

   Slightly soluble in water  

 Applications

1 Pharmaceutical Industry  

    The triazolopyridine scaffold is widely used in designing bioactive molecules such as antiviral antibacterial antifungal or anticancer agents  

    Known to interact with enzymes or receptors due to its planar and electronrich structure  

2 Chemical Synthesis  

    Used as a precursor or intermediate in synthesizing more complex heterocyclic compounds  

    Offers a platform for functionalization at the pyridine and triazole rings

3 Materials Science  

    Investigated for optoelectronic and photophysical properties in the development of advanced materials like organic semiconductors or lightemitting diodes LEDs  

 Reactivity

 Functional Groups  

   Ketone Group CO Reactive in nucleophilic addition or condensation reactions  

   Triazole Ring Stable under most conditions but can participate in substitutions at activated positions  

   Pyridine Ring Capable of electrophilic or nucleophilic aromatic substitutions  

 Tautomerism  

   Can exist as ketoenol tautomers with the equilibrium influenced by solvents pH or temperature  

 Safety and Handling

 Hazards  

   May cause irritation to the skin eyes or respiratory tract  

   Proper precautions should be taken to avoid inhalation or ingestion  

 Handling  

   Use appropriate personal protective equipment PPE including gloves goggles and a lab coat  

   Work in a fume hood or a wellventilated area  

 Storage  

   Store in a cool dry place away from moisture light and strong acids or bases  

 Synthesis Overview

 The compound is often synthesized by cyclization reactions involving hydrazines and pyridine derivatives under specific conditions  

 Reagents like aldehydes acyl chlorides or esters may be used to form the fused system

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